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Analyzing classroom teacher-student consultations: a systemic-multimodal perspective ...
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Analyzing classroom teacher-student consultations: a systemic-multimodal perspective ...
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Non-routine Mathematical Problem-Solving: Creativity, Engagement, and Intuition of STEM Tertiary Students
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The anesthetic approach for endovascular recanalization therapy depends on the lesion site in acute ischemic stroke
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In: Neuroradiology (2021)
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Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study
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In: Sci Rep (2021)
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Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study
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| 8 |
Lesions that do or do not impair digit span: a study of 816 stroke survivors
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In: Brain Commun (2021)
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Damage to Broca’s area does not contribute to long-term speech production outcome after stroke
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In: Brain (2021)
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Changes in Community Clinicians’ Attitudes and Competence following a Transdiagnostic Cognitive Behavioral Therapy Training
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In: Implement Res Pract (2021)
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Brain regions that support accurate speech production after damage to Broca’s area
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In: Brain Commun (2021)
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Evaluating the Impact of Puzzle-based Learning on Creativity, Engagement and Intuition of STEM Tertiary Students
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CorCenCC: Corpws Cenedlaethol Cymraeg Cyfoes – the National Corpus of Contemporary Welsh ...
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Novel Computational Linguistic Measures, Dialogue System and the Development of SOPHIE: Standardized Online Patient for Healthcare Interaction Education ...
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Multimodal estimation and communication of latent semantic knowledge for robust execution of robot instructions
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In: Prof. Roy (2020)
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Patterns of Multidisciplinary Care of Head and Neck Squamous Cell Carcinoma in Medicare Patients
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In: JAMA Otolaryngol Head Neck Surg (2020)
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Black holes, gravitational waves and fundamental physics: a roadmap
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In: Class.Quant.Grav. ; https://hal.archives-ouvertes.fr/hal-01833690 ; Class.Quant.Grav., 2019, 36 (14), pp.143001. ⟨10.1088/1361-6382/ab0587⟩ (2019)
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| 19 |
Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies.
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Fountain, Michael D; Oleson, David S; Rech, Megan E; Segebrecht, Lara; Hunter, Jill V; McCarthy, John M; Lupo, Philip J; Holtgrewe, Manuel; Moran, Rocio; Rosenfeld, Jill A; Isidor, Bertrand; Le Caignec, Cédric; Saenz, Margarita S; Pedersen, Robert C; Morgan, Thomas M; Pfotenhauer, Jean P; Xia, Fan; Bi, Weimin; Kang, Sung-Hae L; Patel, Ankita; Krantz, Ian D; Raible, Sarah E; Smith, Wendy; Cristian, Ingrid; Torti, Erin; Juusola, Jane; Millan, Francisca; Wentzensen, Ingrid M; Person, Richard E; Küry, Sébastien; Bézieau, Stéphane; Uguen, Kévin; Férec, Claude; Munnich, Arnold; van Haelst, Mieke; Lichtenbelt, Klaske D; van Gassen, Koen; Hagelstrom, Tanner; Chawla, Aditi; Perry, Denise L; Taft, Ryan J; Jones, Marilyn; Masser-Frye, Diane; Dyment, David; Venkateswaran, Sunita; Li, Chumei; Escobar, Luis F; Horn, Denise; Spillmann, Rebecca C; Peña, Loren; Wierzba, Jolanta; Strom, Tim M; Parenti, Ilaria; Kaiser, Frank J; Ehmke, Nadja; Schaaf, Christian P
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In: Genetics in medicine : official journal of the American College of Medical Genetics, vol 21, iss 8 (2019)
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Abstract:
PurposeHaploinsufficiency of USP7, located at chromosome 16p13.2, has recently been reported in seven individuals with neurodevelopmental phenotypes, including developmental delay/intellectual disability (DD/ID), autism spectrum disorder (ASD), seizures, and hypogonadism. Further, USP7 was identified to critically incorporate into the MAGEL2-USP7-TRIM27 (MUST), such that pathogenic variants in USP7 lead to altered endosomal F-actin polymerization and dysregulated protein recycling.MethodsWe report 16 newly identified individuals with heterozygous USP7 variants, identified by genome or exome sequencing or by chromosome microarray analysis. Clinical features were evaluated by review of medical records. Additional clinical information was obtained on the seven previously reported individuals to fully elucidate the phenotypic expression associated with USP7 haploinsufficiency.ResultsThe clinical manifestations of these 23 individuals suggest a syndrome characterized by DD/ID, hypotonia, eye anomalies,feeding difficulties, GERD, behavioral anomalies, and ASD, and more specific phenotypes of speech delays including a nonverbal phenotype and abnormal brain magnetic resonance image findings including white matter changes based on neuroradiologic examination.ConclusionThe consistency of clinical features among all individuals presented regardless of de novo USP7 variant type supports haploinsufficiency as a mechanism for pathogenesis and refines the clinical impact faced by affected individuals and caregivers.
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Keyword:
2.1 Biological and endogenous factors; Adolescent; Autism; Autism Spectrum Disorder; Behavioral and Social Science; Brain Disorders; Child; Chromosome Deletion; Clinical Research; Clinical Sciences; Congenital Structural Anomalies; corpus callosum thinning; DNA-Binding Proteins; Genetics; Genetics & Heredity; Genome; Haploinsufficiency; Human; Humans; Infant; Intellectual and Developmental Disabilities (IDD); Intellectual Disability; Language Development Disorders; Mental Health; neurodevelopment; Neurodevelopmental Disorders; Neurosciences; Newborn; Nuclear Proteins; Pediatric; Phenotype; Preschool; Problem Behavior; Proteins; speech delay; USP7; white matter paucity; Whole Exome Sequencing
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URL: https://escholarship.org/uc/item/0h47s4s0
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Black holes, gravitational waves and fundamental physics: a roadmap
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